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KMID : 0383119610090010037
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Journal of Aerospace Medicine
1961 Volume.9 No. 1 p.37 ~ p.46
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Abstract
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The Post-Mortem lactic acid concentrations in the brain of mice were observed. Mice were exposed to hypoxia (for one hour at simulated altitude of 20,000, 25,000 and 30,000 feet, in low pressure chamber), carbon monoxide atmosphere (0.3, 0.7 and 1.0% in air), and positive radial acceleration (for 5-20 minutes at 5, 10, 15, 20 and 30 g). Brain samples were analyzed for lactic acid concentrations at zero, 1, 3, 6 and 20 hours after death of animals. Brain was stored in 100% nitrogen for 3 hours before chemical analysis. Care was taken to minimize the loss or gain of blood from the brain tissue. The following results were obtained.
1. Lactic acid concentration of brain tissue immediately after death in normal control group was 80 mg/100 gm tissue. This value is low compared to that of dog, rabbit and rat by 40 mg/100 gm.
2. Brain lactic acid concentrations both in control and experimental groups increased as time elapsed after death. Concentration 20 hours after death in control group, however,
never reached to those of zero hour values of experimental groups.
3. In simulated altitude experiment higher than 0,000 feet the brain lactic acid concentration showed a higher value than that of control group. The difference was more than 40 mg/100 gm. The increase in lactic acid concentration generally parallel to the length of exposure and altitude. The rate of increase became smaller from 3 hours after death.
4. In carbon monoxide poisoned mice, there was a marked accumulation, of post-mortem brain lactic acid. This accumulation, however showed no relationship between the concentration of carbon monoxide in inhaling air.
5. Ante-mortem positive radial acceleration exposure to mice resulted in the accumulation of brain lactic acid. The magnitude of accumulation was smaller compared to the hypoxia and carbon a monoxide groups. Accumulation of brain lactic acid increased with the magnitude of acceleration but not with the time of exposure to acceleration.
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